Botox and other Botulinum toxin-A products can significantly improve acne by blocking acetylcholine (a key neurotransmitter released in the body) in sebocytes and inducing paralysis on the smooth muscles of follicles. Typically, 20 of Botox/Xeomin or 50 units of Dysport are hyperdiluted and injected throughout the area of concern. Effects can last up to 3 months.